Function following limb salvage procedures for bone sarcoma

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National Secretary, Australian Sarcoma Group, Victoria.


Abstract

Bone sarcomas are the fourth most common cancer in individuals under 25 years. Osteosarcoma is the most common form of sarcoma in this population, with distal femur the most common tumour location. Before chemotherapy protocols were instituted, a 20% overall survival with limb amputation was quoted, however with chemotherapy and limb salvage or limb preservation surgery that figure has improved dramatically to 60-75% at five years. This paper looks at the functional outcome of limb salvage surgery around the knee. It shows that after a tumour resection with prosthetic reconstruction, the oxygen demands on the body are significantly raised by muscular co-contraction activity in both legs as an adaptive gait.


Bone sarcomas are the fourth most common cancer in individuals under 25 years.1,2 Osteosarcoma is the most common form of sarcoma in this population and is commonly observed in the rapidly growing metaphyseal areas of extremity long bones.3

The primary consideration is always the capacity to achieve a wide resection with clear surgical margins, leaving the different modalities of reconstruction to be practised as secondary considerations. Some prostheses function better than others in different joints leading to favoured techniques for different resections types. The distal femur is an obvious case of an excellent functional reconstruction compared with amputation. As time progresses the two recent major surgical voids of the proximal tibia and the shoulder joint are also improving with prosthesis and encircling mesh attachments. In general the lower limb is much more amenable to prosthetic reconstruction and allows good ambulation with some limitations, albeit vastly better than amputation. The upper limb, although not quite as readily reconstructed with a good outcome functionally by contemporary standards, does better due to the fact that “any arm is a good arm” to allow limited grasp and pinch either in the hand or the against the chest wall.

Pelvic resections and the required reconstructions pose major long term viability problems with many of the available reconstructive options, all of which have an initial success rate of approximately 30%, requiring further reconstructions. There has been a recent groundswell of activity with regards to non-reconstruction and production of a pseudoarthrosis, due to the long-term failure of most of these options. Diaphyseal resections of mid segments of bone generally do well with availability of fibula direct transfer, prosthetic segments, or bone distraction techniques such as the Illizarov frame, allowing for a diverse array of treatments. Below the mid tibia very few simple options exist except amputation, although the aggressiveness of the disease and the advent of plastic surgical soft tissue flaps have widened the reconstructive options and helped with avoidance of amputation. Current options for limb reconstruction after sarcoma include amputation, rotationplasty, arthrodesis and arthroplasty.

Rotationplasty is an operation where the foot is placed backwards on the knee and is ideal for the ages of six to nine. It is not well accepted in western society, however, is still popular in low resource countries that struggle to afford contemporary prosthetic options. See figures one and two.

Figure 1: Rotationplasty intraoperative surgical technique Figure 2: Final result Rotationplasty with below knee prosthesis

Arthrodesis, or fusion of the affected joint, is practised less and less, however is still popular for the shoulder and the pelvis where prosthetic options are limited.

Arthroplasty or joint replacement is most popular with the use of a mega-prosthesis, either in isolation or with allograft. Reconstruction of a limb to near normal physical appearance is possible, but there are ambulatory functional limitations. See figure three.

Figure 3: Distal Femur prosthetic replacement intraopertaively following tumour resection

Limb-salvage procedures have become increasingly popular for the treatment of osteosarcoma due to functional and physiological benefits over traditional amputative procedures.4.5 A low recurrence of osteosarcoma (< 10%) has been reported following limb salvage procedures for high grade sarcomas.6,7 Previous locomotor research has shown that limb salvage patients often adopt a ‘stiff-legged’ gait pattern post-surgery, that is characterised by muscular co-contraction.8-12 The stiff-legged pattern has been attributed to a number of factors including: proprioceptive impairment; quadriceps weakness; avoidance of shear forces; disruption of the mechanical advantage mechanism (ie. patella and patella tendon); instability; pain; and habit.13,14,10,15,12,16

The purpose of this paper was to apply three dimensional gait analysis methods to a group of intra-articular knee osteosarcoma patients greater than one year post surgery. A retrospective subjective outcome study was undertaken on 20 limb salvage patients (10 female, 10 male) recruited from the Queensland Bone Tumour Registry. Kinematic data were collected using an eight camera real time motion analysis system. Foot ground reaction forces were recorded with the use of three force platforms. Loading response knee flexion in the affected lower limb was reduced compared to the unaffected lower limb (P < 0.001) and the control group (P < 0.001). Multiple regression analysis revealed that the amount of soft tissue removal was the most predictive factor of function following limb salvage surgery; this was followed by knee extension strength, knee flexion range of motion, time from surgery and length of bone resection. The results of this study suggest that following limb salvage patients use a variety of techniques aimed at reducing the movement demand at the knee and hip. These techniques appeared to be a compensation for pain, stability and/or weakness.

Findings

Limb salvage patients demonstrated prolonged rectus femoris activation in both their affected and unaffected lower limbs when compared with the control participants. Limb salvage participants also displayed significantly prolonged activation of the medial hamstrings and the medial gastrocnemius in their affected lower limb when compared with the control subjects. The medial hamstrings activity was observed to be significantly longer in their affected lower limb when compared to their unaffected lower limb. Assessment of rectus femoris/medial hamstring co-contraction showed that limb salvage participants had a higher quadriceps to hamstring co-contraction index in both lower limbs when compared to the control subjects, with their affected lower limb showing a trend for a higher index compared to their unaffected lower limb.

There were no group differences in free walking velocity or relative velocity. Gross energy expenditure, net energy expenditure and energetic cost measurements were all significantly higher in the limb salvage participants. Furthermore, mass specific values of energy consumption and cost of transport were significantly higher in the limb salvage participants. 

Relative walking efficiency for the limb salvage population was calculated as 80%. Mass-specific net cost of transport was higher in the limb salvage participants compared to the control participants, for a given relative velocity. The ANOVA test analysis (Analysis Of Variance) confirmed the difference between the heights of the two slopes (p < 0.001) but not the gradient.

Pearson correlations showed negative relationships between knee extension strength (R = -0.5, p < 0.5), knee flexion range of motion (R = -0.46, p < 0.05) and energy cost. Furthermore, Pearson correlations showed positive relationships between knee extensor strength and rectus femoris activation time (R = 0.39, p < 0.05) and between knee extensor strength and rectus femoris to hamstring co-contraction percentage (R = 0.43, p < 0.5). Time from surgery was not related to any of the electromyographic or energetic parameters assessed. Finally, Pearson correlations revealed that there were small but insignificant relationships between the electromyography findings and the energetic results.

Conclusion

Prolonged activation patterns were observed in muscles surrounding the knee in total knee replacement patients. As a typical total knee replacement stiff-legged gait pattern was adopted, the prolonged activations were not related to increased moment requirements, suggesting that the activity patterns were related to knee stability and may have reflected proprioceptive deficits at this site.

Electromyographic patterns in the unaffected lower limb suggested that alterations in gait involved higher neuronal centres. These results are important for the development of rehabilitation programs, as they suggest that an overall reprogramming of the gait pattern occurs post-operatively, thereby limiting the impact of conventional strength and stretching interventions.

On consideration of quality of life factors, limb salvage alone versus amputation has significant value in allowing the person to maintain their ambulatory independence. On a low functional level with activities of daily living, ambulatory independence has returned without crutches and the ability to walk up and down stairs and long distances. At a higher functional level many return to sport with an appropriate disability grading for active competition.

Prosthetic reconstruction is not a normal limb, but much closer to normality in any other reconstructive option, with some added increased physical oxygen demands due to heightened muscle activity.

References

1. Homa DM, Sowers MR, Schwartz AG. Incidence and survival rates of children and young adults with osteogenic sarcoma. Cancer.1991;67(8):2219-2223.
2. Young JL, Percy CL, Asire AJ. editors. Cancer incidence and mortality in the United States, 1973-77. In: Young JL, Percy CL, Asire AJ, editors. Surveillance, Epidemiology, and End Results: incidence and mortality data, 1973-1977.Natl Cancer Inst Monogr. (Vol. 57). Washington, DC:NIH, 1981.
3. Dorfman HD, Czerniak B. Bone cancers. Cancer. 1995;75(1 Suppl):203- 210.
4. Harris IE, Leff AR, Gitelis S, Simon MA. Function after amputation, arthrodesis, or arthroplasty for tumors about the knee. J Bone Joint Surg Am. 1990;72(10):1477-1485.
5. Otis JC, Lane JM, Kroll MA. Energy cost during gait in osteosarcoma patients after resection and knee replacement and after above-the-knee amputation. J Bone Joint Surg Am. 1985;67(4):606-611.
6. Malawer M, Buch R, Reaman G, Priebat D, Potter B, Khurana J. Impact of two cycles of preoperative chemotherapy with intraarterial cisplatin and intravenous doxorubicin on the choice of surgical procedure for high-grade bone sarcomas of the extremities. Clin Orthop Relat Res. 1991;(270):214- 222.
7. Simon MA, Aschliman MA, Thomas N, Mankin HJ. Limb-salvage treatment versus amputation for osteosarcoma of the distal end of the femur. J Bone Joint Surg Am. 1986;68(9):1331-1337.
8. Benedetti MG, Bonato P, Catani F, D’Alessio T, Knaflitz M, Marcacci M, et al. Myoelectric activation pattern during gait in total knee replacement: relationship with kinematics, kinetics, and clinical outcome. IEEE Trans Rehabil Eng. 1999;7(2):140-149.
9. Benedetti MG, Catani F, Donati D, Simoncini L, Giannini S. Muscle performance about the knee joint in patients who had distal femoral replacement after resection of a bone tumor. An objective study with use of gait analysis. J Bone Joint Surg Am. 2000;82-A(11):1619-1625.
10. De Visser E, Mulder T, Schreuder HW, Veth RP, Duysens J. Gait and electromyographic analysis of patients recovering after limb-saving surgery. Clin Biomech (Bristol, Avon). 2000;15(8):592-599.
11. Kawai A, Backus SI, Otis JC, Inoue H, Healey JH. Gait characteristics of patients after proximal femoral replacement for malignant bone tumour. J Bone Joint Surg Br. 2000;82(5):666-669.
12. Rompen JC, Ham SJ, Halbertsma JP, van Horn JR. Gait and function in patients with a femoral endoprosthesis after tumor resection: 18 patients evaluated 12 years after surgery. Acta Orthop Scand. 2002;73(4):439-446.
13. Andriacchi TP, Alexander EJ, Goodman SB. Understanding the role of functional adaptations in patients with total knee replacements. International conference on knee replacement; Int Conf on knee replacement, Imeche Headquarters, London; 1999. p.1974–2024.
14. Benedetti MG, Catani F, Bilotta TW, Marcacci M, Mariani E, Giannini S. Muscle activation pattern and gait biomechanics after total knee replacement. Clin Biomech (Bristol, Avon). 2003;18(9):871-876.
15. Dorr LD, Ochsner JL, Gronley J, Perry J. Functional comparison of posterior cruciate-retained versus cruciate-sacrificed total knee arthroplasty. Clin Orthop. 1988;(236):36-43.
16. Winter DA, editor. Assessment of pathlogical gait. In: The Biomechanics and Motor Control of Gait: Normal, Elderly and Pathological. 2nd ed. Ontario: Waterloo Biomechanics;1991.

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