R Kumar (Ed)
Springer-Verlag US (2004)
ISBN: 1-4020-7822-6 327 pages plus index
The pathogenic mechanisms giving rise to cancer frequently involve altered signal transduction pathways. The elucidation of signal transduction pathways in cancer cells, both at the proteomic and the genomic levels, has led to the design of drug molecules as cancer treatments that are intended to act at specific proteins of the signal transduction cascade. Many drug molecules directed against a wide range of signal transduction elements are being evaluated as potential anticancer therapies and several are currently in clinical trials; others are still in preclinical research and development. This book contains a collection of excellent reviews on various signalling molecules and their suitability as drug targets in cancer treatments. Written by internationally renowned scientists, all leaders in their fields, it examines the most important signalling pathways in cells and provides a clear understanding of the different components of each pathway and their complex interactions. It also describes current knowledge on the design, synthesis, and evaluation of the biochemical and biological activities of inhibiting molecules. Specific topics include a biomolecular survey of cell signals; the role of cell-to-cell communication, growth factor and hormone signalling in cancer; cell cycle deregulation and cell migration and adhesion.
The chapters of this book integrate elegantly with one another and provide the reader with both broad and comprehensive viewpoints. Remarkably current and up-to-date, the book promises to be a core text for university courses in cell signaling and molecular cell biology, and a valuable reference book for all scientists whose work involves or is interested in signal transduction, cancers or indeed any human disease where the pathogenic mechanism of disease involves signalling molecules.
Readership: Immunologists, cell biologists, molecular biologists, biochemists, pharmacologists, clinical researchers and students
Institute for Medical Research and Public Health